Senior Associate Scientist, Synthesis, RNA Process Sciences Job at Bristol Myers Squibb, Cambridge, MA

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  • Bristol Myers Squibb
  • Cambridge, MA

Job Description

Senior Associate Scientist position supporting RNA drug substance programs from preclinical through early-stage development. The role involves optimizing in vitro transcription and synthesis processes, performing hands-on experimentation, and collaborating with research and manufacturing teams to advance circular and linear mRNA therapeutics.

Responsibilities

  • Perform high throughput optimization and characterization of in vitro transcription, circularization, and DNase reactions
  • Support RNA drug substance synthesis process definition and scale-up activities
  • Conduct experiments using automated or data-rich setups to confirm robust process performance
  • Collaborate with research teams on transition from drug candidate nomination to clinical manufacturing
  • Participate in technology transfer activities to GMP manufacturing sites for RNA programs

Requirements

  • BS in biochemistry, chemical engineering, or related field plus 4+ years relevant experience; or MS plus 2+ years experience
  • Proficiency with automated liquid handlers, small-scale bioreactors, and reactor design
  • Working knowledge of design of experiments and multivariate data analysis
  • Experience with process analytics techniques including HPLC, CE, and gel electrophoresis
  • Hands-on experience with liquid handling systems, high throughput workflow design, and LIMS/ELN platforms preferred
  • Knowledge of cGMP, ICH guidelines, and quality-by-design principles preferred

Compensation: $96,010 - $116,339

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